AQP4 (205-215) (TFA)

AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4) . AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) [1][2].

Product Specifications

UNSPSC

12352209

Target

Aquaporin

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(N)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(C(F)(F)F)O.[x]

Molecular Formula

C48H75N13O17S.xC2HF3O2

Molecular Weight

1138.25 (free acid)

References & Citations

[1]Ali Maisam Afzali, et al. B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. 2024 Mar;627 (8003) :407-415.|[2]Anna-Lena Vogel, et al. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol. 2017 Mar;47 (3) :458-469.