AQP4 (205-215)
AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4) . AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) [1][2].
Product Specifications
CAS Number
[2891466-35-4]
UNSPSC
12352209
Target
Aquaporin
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(N)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C48H75N13O17S
Molecular Weight
1138.25
References & Citations
[1]Ali Maisam Afzali, et al. B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. 2024 Mar;627 (8003) :407-415.|[2]Anna-Lena Vogel, et al. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol. 2017 Mar;47 (3) :458-469.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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