AQP4 (201-220)

AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord) . AQP-4 is a target antigen in neuromyelitis optica[1].

Product Specifications

CAS Number

[2104700-59-4]

UNSPSC

12352209

Target

Aquaporin

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](CC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](N)CC2=CN=CN2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N4[C@@H](CCC4)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(NCC(N5[C@@H](CCC5)C(O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C97H143N27O27S

Molecular Weight

2151.40

References & Citations

[1]Afzali AM, et al. AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD. Acta Neuropathol Commun. 2025 Feb 11;13 (1) :27. |[2]Vogel A L. Adaptive immune responses to AQP4 in a murine model for neuromyelitis optica[D]. Technische Universität München, 2023.|[3]Afzali AM, et al. B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. 2024 Mar;627 (8003) :407-415.|[4]Arellano G, et al. Interferon-γ controls aquaporin 4-specific Th17 and B cells in neuromyelitis optica spectrum disorder. Brain. 2024 Apr 4;147 (4) :1344-1361.