Amilo-5MER

Amilo-5MER (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS) . Amilo-5MER is promising for research of autoimmune diseases and chronic inflammatory diseases[1].

Product Specifications

CAS Number

[1860001-61-1]

Product Name Alternative

5-MP

UNSPSC

12352209

Target

Amyloid-β; Interleukin Related

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology

Smiles

CC(C)[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CCSC)=O)=O)=O)=O

Molecular Formula

C23H40N6O9S

Molecular Weight

576.66

References & Citations

[1]Hemed-Shaked M, et al. MTADV 5-MER peptide suppresses chronic inflammations as well as autoimmune pathologies and unveils a new potential target-Serum Amyloid A. J Autoimmun. 2021 Nov;124:102713.