RAD21 (356–395) (TFA)

RAD21 (356–395) TFA is a peptide encompassing amino acids 356 to 395 of the RAD21 protein, which can be used to study the interaction mechanism between STAG1 and RAD21. The equilibrium dissociation constant (KD) value for the interaction between RAD21 (356–395) TFA and STAG1 is 127 nM[1].

Product Specifications

UNSPSC

12352209

Target

Others

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C([C@H]1NCCC1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N4[C@H](C(O)=O)CCC4)=O)[C@@H](C)O)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CC5=CC=CC=C5)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)CC6=CNC7=CC=CC=C67)=O)CC(C)C)=O)CCC3)=O)CCC(N)=O)=O)C)=O)CCC2)=O)CC(C)C)=O)CO)=O)CC8=CC=CC=C8)=O)CC(C)C)=O)CCCCN)=O)CCC(O)=O)=O)C(C)C)=O)=O)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCCCN)=O)CC9=CNC%10=CC=CC=C9%10)=O)CCSC)=O)CCSC)=O)CC(C)C)=O)CCCCN)=O)CCCCN)=O)[C@@H](C)O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C217H350N56O53S3.xC2HF3O2

Molecular Weight

4687.64 (free base)

References & Citations

[1]van der Lelij P, et al. STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Life Sci Alliance. 2020 May 28;3 (7) :e202000725.