Roseltide rT1
Roseltide rT1 is a neutrophil elastase inhibitor (IC50=0.47 μM) rich in cysteine and one of the Roseltide (rT1-rT8) family members. Roseltide rT1 improves cAMP accumulation stimulated by neutrophil elastase in vitro, showing potential for inhibiting related diseases[1].
Product Specifications
CAS Number
2206692-95-5
UNSPSC
12352209
Target
Elastase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N2[C@H](C(NC3)=O)CCC2)=O)CO)=O)CC(N)=O)=O)N[C@H](C(N4[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]1CSSC[C@H](NC5=O)C(N[C@H](C(O)=O)C)=O)=O)=O)CO)=O)CC(C)C)=O)C)=O)C(C)C)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]5[C@H](CC)C)=O)=O)CC6=CC=CC=C6)=O)[C@H](CC)C)=O)=O)[C@H](CC)C)=O)=O)=O)CCCNC(N)=N)=O)CCC4)=O)[C@H](CC)C
Molecular Formula
C110H177N31O31S6
Molecular Weight
2622.16
References & Citations
[1]Loo S, et al. Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa. Sci Rep. 2016 Dec 19;6:39401.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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