D-CopA3

D-CopA3 is the inhibitor for MDM2 and the activator for p53 signaling pathway. D-CopA3 exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO (IC50=15-18 μM), induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of cell cycle inhibitory protein p21Cip1/Waf1, enhances the mucosal barrier function and reduces penetration of inflammatory mediators. D-CopA3 exhibits anti-inflammtory activity in mouse C. difficile toxin A-induced acute enteritis models and DSS (HY-116282) -induced chronic colitis models. D-CopA3 exhibits antitumor efficacy in mouse HCT-116 xenograft models[1][2].

Product Specifications

CAS Number

[1426227-11-3]

UNSPSC

12352209

Target

Autophagy; MDM-2/p53

Related Pathways

Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

NCCCC[C@H](C(N)=O)NC([C@@H](CCCCN)NC([C@@H](CCCNC(N)=N)NC([C@@H](CC(C)C)NC([C@@H](C)NC([C@@H]([C@H](C)CC)NC([C@@H](CSSC[C@@H](NC([C@@H](CC(C)C)NC([C@H](N)CC(C)C)=O)=O)C(N[C@H]([C@H](C)CC)C(N[C@H](C)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCCN)C(N[C@@H](C(N)=O)CCCCN)=O)=O)=O)=O)=O)=O)NC([C@@H](CC(C)C)NC([C@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C96H184N30O18S2

Molecular Weight

2110.81

References & Citations

[1]Kim DH, et al., The Insect Peptide CopA3 Increases Colonic Epithelial Cell Proliferation and Mucosal Barrier Function to Prevent Inflammatory Responses in the Gut. J Biol Chem. 2016 Feb 12;291 (7) :3209-23.|[2]Dey DK, et al., CopA3 peptide inhibits MDM2-p53 complex stability in colorectal cancers and activates p53 mediated cell death machinery. Life Sci. 2023 Apr 1;318:121476.