NOTA-P2-RM26

NOTA-P2-RM26 is an antagonist of Bombesin (HY-P0195) analogs, and the gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for prostate cancer visualization. NOTA-P2-RM26 is labeled with 111In and 68Ga for prostate cancer imaging studies using PET and SPECT/CT[1].

Product Specifications

CAS Number

[1446005-10-2]

UNSPSC

12352209

Target

Bombesin Receptor

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

97.20

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(CN(CCN(CC1)CC(O)=O)CCN1CC(NCCOCCOCC(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@H](C(N)=O)CC(C)C)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O

Molecular Formula

C73H110N18O19

Molecular Weight

1543.76

References & Citations

[1]Varasteh Z, et al. Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging. Bioconjug Chem. 2013 Jul 17;24 (7) :1144-53.