UK140

UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with Ki of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research[1].

Product Specifications

UNSPSC

12352209

Target

PAI-1

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)CSC2)=O)CO)=O)CO)=O)CCC1)=O)CC(O)=O)=O)C(C)C)=O)=O)CSC3)=O)=O)CO)=O)CC4=CC=CC=C4)=O)CCCCN)=O)CO)=O)CC(N)=O)=O)CSCC5=CC2=CC3=C5

Molecular Formula

C72H105N19O25S3

Molecular Weight

1732.91

References & Citations

[1]Mazzocato Y, et al., A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue. Bioorg Med Chem. 2023 Nov 15;95:117499.