HL2-m5
HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM[1].
Product Specifications
CAS Number
2130846-15-8
UNSPSC
12352209
Target
Hedgehog
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Purity
98.06
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CCC(O)=O)=O)C)=O)CCSC)=O)CC(O)=O)=O)CCSC)=O)CSCCOC2=CC=C(C=C2)C[C@@H]1NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC(C)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O
Molecular Formula
C70H101N15O24S3
Molecular Weight
1632.83
References & Citations
[1]Owens AE, et al., Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. J Am Chem Soc. 2017 Sep 13;139 (36) :12559-12568.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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