Pep1-DNP conjugate 9

Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with KD of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models[1].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; FGFR; Peptide-Drug Conjugates (PDCs)

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C([C@@H](N)CC1=CC=C(O)C=C1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(NCCOCCOCCOCCOCCOCCOC3=CC=C(C=C3[N+]([O-])=O)[N+]([O-])=O)=O)=O)=O)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCC2)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CC(C)C)=O)C)=O)C(C)C)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=CC=CC=C56)=O)CO)=O)CO)=O)CC7=CC=C(O)C=C7)=O)CCCCN)=O)CCCNC(N)=N)=O)CO)=O)CCCNC(N)=N

Molecular Formula

C135H207N37O41

Molecular Weight

3004.31

References & Citations

[1]Li X, et al., Chemoenzymatic Synthesis of DNP-Functionalized FGFR1-Binding Peptides as Novel Peptidomimetic Immunotherapeutics for Treating Lung Cancer. J Med Chem. 2024 Sep 12;67 (17) :15373-15386.