DCNP
DCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses[1].
Product Specifications
UNSPSC
12352209
Target
Natriuretic Peptide Receptor (NPR)
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Purity
95.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CCCCN)N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NC1)=O)CC(C)C)=O)=O)CO)=O)CCSC)=O)CO)=O)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)CSSC[C@H](NC1=O)C(O)=O)=O)=O)CCCCN)=O)CO)=O)CC(C)C)=O)=O)=O)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN
Molecular Formula
C141H248N38O36S3
Molecular Weight
3147.91
References & Citations
[1]Lu Z, et al., Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies. Sci Transl Med. 2024 Aug 21;16 (761) :eadn0904.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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