CPI1
CPI1 is a potent and highly specific multidrug resistance protein 1 (MRP1) inhibitor. CPI1 inhibits MRP1 (Ki: 100 nM) with nanomolar potency but shows minimal inhibition of P-glycoprotein (Pgp) . CPI1 and LTC4 compete to bind to the same site of MRP1, inhibiting ATP hydrolysis and substrate transport. CPI1 can be used to study drug delivery and chemotherapy resistance in cancer[1].
Product Specifications
CAS Number
3085809-95-3
UNSPSC
12352209
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.34
Solubility
DMSO : 50 mg/mL
Smiles
O=C(CSC[C@H](NC1=O)C(O)=O)N[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=CC=CC=C56)=O)CC7=CNC=N7)=O)CC(C)C)=O)CC(N)=O)=O)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=C(O)C=C%11
Molecular Formula
C111H131N23O30S
Molecular Weight
2299.43
References & Citations
[1]Pietz HL, et al. A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Proc Natl Acad Sci U S A. 2023 Mar 14;120 (11) :e2220012120.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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