CPI1

CPI1 is a potent and highly specific multidrug resistance protein 1 (MRP1) inhibitor. CPI1 inhibits MRP1 (Ki: 100 nM) with nanomolar potency but shows minimal inhibition of P-glycoprotein (Pgp) . CPI1 and LTC4 compete to bind to the same site of MRP1, inhibiting ATP hydrolysis and substrate transport. CPI1 can be used to study drug delivery and chemotherapy resistance in cancer[1].

Product Specifications

CAS Number

[3085809-95-3]

UNSPSC

12352209

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.34

Solubility

DMSO : 50 mg/mL

Smiles

O=C(CSC[C@H](NC1=O)C(O)=O)N[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)CC2=CC=CC=C2)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC3=CC=C(O)C=C3)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=CC=CC=C56)=O)CC7=CNC=N7)=O)CC(C)C)=O)CC(N)=O)=O)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=C(O)C=C%11

Molecular Formula

C111H131N23O30S

Molecular Weight

2299.43

References & Citations

[1]Pietz HL, et al. A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Proc Natl Acad Sci U S A. 2023 Mar 14;120 (11) :e2220012120.