HVEM (14-39)
HVEM (14-39) is a B- and T-lymphocyte attenuator (BTLA) peptide inhibitor. HVEM (14-39) can be combined with BTLA with a KD of 0.102 μM. HVEM (14-39) enhances the activation and proliferation of T cells by regulating the expression of BTLA and HVEM in T cells, and promotes the transformation of cells into effector memory T cells. HVEM (14-39) inhibits tumor cell proliferation and promotes late apoptosis. HVEM (14-39) has immunomodulatory effects and can be used in the study of cancer[1].
Product Specifications
UNSPSC
12352209
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N1C(C(NC(C(N[C@H](C(N[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3C)=O)CCC(O)=O)=O)CCCCN)=O)C(C)C)=O)CCCNC(N)=N)=O)CC4=CC=C(O)C=C4)=O)=O)CCC2)=O)CO)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N6[C@H](C(N)=O)CCC6)=O)CCC(O)=O)=O)=O)CCCCN)=O)CCC1)=O)CSSC[C@H](NC3=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]5C(C)C)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)=O)CO)=O)CCC(O)=O
Molecular Formula
C115H182N32O40S4
Molecular Weight
2781.13
References & Citations
[1]Wojciechowicz K, et al. Targeting BTLA with the peptide inhibitor HVEM (14-39) - A new way to restore the activity of T cells in melanoma. Biomed Pharmacother. 2024 Jun;175:116675.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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