PIYLGGVFQ
PIYLGGVFQ is a peptide inhibitor for TNF-α. PIYLGGVFQ inhibits TNF-α-mediated apoptosis, NF-κB nuclear translocation and activation. PIYLGGVFQ exhibits anti-arthritic activity in the CIA mouse model[1].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; NF-κB; TNF Receptor
Related Pathways
Apoptosis; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]3NCCC3
Molecular Formula
C49H72N10O12
Molecular Weight
993.16
References & Citations
[1]Sahu D, et al., Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity. Sci Rep. 2024 Jun 5;14 (1) :12935.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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