KS-58

KS-58 is a KRpep-2d (HY-P3277) derivative. KS-58 is a K-Ras (G12D) inhibitory peptide that selectively binds K-Ras. KS-58 can enter cells and block intracellular Ras interaction with effector proteins. KS-58 inhibits the proliferation of tumor cells and has antitumor activity[1][2].

Product Specifications

CAS Number

[2549046-46-8]

UNSPSC

12352209

Target

Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Smiles

O=C([C@H](CO)NC([C@H](CCCCCCC)NC([C@H]1NC([C@H](CCCC)NC([C@@H]2CCCN2C(CCNC3=O)=O)=O)=O)=O)=O)N[C@H](C(N[C@H](C(N4[C@H](C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H]3CSCCCSC1)=O)=O)CCC4)=O)CC(O)=O)=O)CC7=CC=C(F)C=C7

Molecular Formula

C64H89FN12O14S2

Molecular Weight

1333.59

References & Citations

[1]Sakamoto K, et al. Nanoformulation of the K-Ras (G12D) -inhibitory peptide KS-58 suppresses colorectal and pancreatic cancer-derived tumors. Sci Rep. 2023 Jan 10;13 (1) :518. |[2]Sakamoto K, et al Generation of KS-58 as the first K-Ras (G12D) -inhibitory peptide presenting anti-cancer activity in vivo. Sci Rep. 2020 Dec 10;10 (1) :21671.