ATWLPPRAANLLMAAS

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis.[1][2].

Product Specifications

CAS Number

1228447-26-4

UNSPSC

12352209

Target

Apoptosis; Bcl-2 Family; Caspase; ERK; MEK; PARP; Raf; Ras

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](N)C)=O)=O)CC3=CNC4=CC=CC=C34)=O

Molecular Formula

C76H123N21O20S

Molecular Weight

1682.98

References & Citations

[1]Wu D, et al. Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice[J]. Peptides, 2010, 31 (5) : 850-864.|[2]Wu D, et al. Peptide V3 inhibits the growth of human hepatocellular carcinoma by inhibiting the Ras/Raf/MEK/ERK signaling pathway[J]. Journal of Cancer, 2019, 10 (7) : 1693.