MAPI
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection[1].
Product Specifications
CAS Number
1260620-30-1
UNSPSC
12352209
Target
Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)/C=C/C(OCC)=O)=O)=O)=O)[C@H](CCC(O)=O)NC(C)=O
Molecular Formula
C36H53N7O11
Molecular Weight
759.85
References & Citations
[1]Hussey RJ, et al. A structural study of norovirus 3C protease specificity: binding of a designed active site-directed peptide inhibitor. Biochemistry. 2011 Jan 18;50 (2) :240-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2
Frequently Asked Questions
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