MAPI

MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection[1].

Product Specifications

CAS Number

[1260620-30-1]

UNSPSC

12352209

Target

Virus Protease

Related Pathways

Anti-infection

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)/C=C/C(OCC)=O)=O)=O)=O)[C@H](CCC(O)=O)NC(C)=O

Molecular Formula

C36H53N7O11

Molecular Weight

759.85

References & Citations

[1]Hussey RJ, et al. A structural study of norovirus 3C protease specificity: binding of a designed active site-directed peptide inhibitor. Biochemistry. 2011 Jan 18;50 (2) :240-9.