RI-OR2

RI-OR2, a retro-inverso peptide, is an amyloid-β (Aβ) oligomerization inhibitor. RI-OR2 binds to immobilized β-Amyloid (1-42) monomers and fibrils, with an apparent Kd of 9-12 μM, and also acted as an inhibitor of Aβ (1-42) fibril extension[1].

Product Specifications

CAS Number

1219627-58-3

UNSPSC

12352209

Target

Amyloid-β

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(NCC(N[C@H](CC1=CC=CC=C1)C(N[C@H](CC2=CC=CC=C2)C(N[C@H](C(C)C)C(N[C@H](CC(C)C)C(N[C@H](CCCCN)C(NCC(N[C@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CCCNC(N)=N)NC(C)=O

Molecular Formula

C53H85N17O10

Molecular Weight

1120.35

References & Citations

[1]Mark Taylor, et al. Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease. Biochemistry. 2010 Apr 20;49 (15) :3261-72.