S9-CMC1 (TFA)
S9-CMC1 TFA is a covalent peptide lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 value of 2.53 μM. S9-CMC1 TFA specifically recognizes Cys360 in the enzyme-active region. S9-CMC1 TFA inhibits LSD1 activity, increasing H3K4me1 and H3K4me2 levels, leading to G1 cell cycle arrest and apoptosis and inhibiting cell proliferation. S9-CMC1 TFA significantly inhibits tumor growth in A549 xenograft animal models[1].
Product Specifications
UNSPSC
12352209
Target
Apoptosis; Histone Demethylase
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSCC1=CC=CC2=C1)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC[S+](C2)C)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]7N(C(C)=O)CCC7.[O-]C(C(F)(F)F)=O
Molecular Formula
C97H151F3N32O17S2
Molecular Weight
2158.57
References & Citations
[1]Luo Q, et al. Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region. J Med Chem. 2023 Nov 23;66 (22) :15409-15423.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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