Polyglutamine binding peptide 1

Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ) . Polyglutamine binding peptide 1 inhibits polyQ protein aggregation in vitro and suppresses polyQ-induced cell death in cell culture[1].

Product Specifications

CAS Number

[274914-75-9]

UNSPSC

12352209

Target

Huntingtin

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N7[C@@H](CCC7)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

Molecular Formula

C72H90N16O16

Molecular Weight

1435.58

References & Citations

[1]Yoshitaka Nagai, et al. Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. Hum Mol Genet. 2003 Jun 1;12 (11) :1253-9.