Corza6

Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a Kd of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) [1].

Product Specifications

UNSPSC

12352209

Target

Proton Pump; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Smiles

O=C([C@@H](N)CO)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(NCC(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CSSC[C@H](NC4=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCCCN)=O)=O)CC5=CNC6=CC=CC=C56)=O)C(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC(O)=O)=O)CO)=O)CC(O)=O)=O)C)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CCSC)=O)CC8=CC=CC=C8)=O)CCCCN)=O)CO)=O)[C@@H](C)O)=O)CC9=CC=CC=C9)=O)CC%10=CC=CC=C%10)=O)C(C)C)=O)CC%11=CNC%12=CC=CC=C%11%12)=O)CCCCN)=O)=O)CCC2)=O)CCC(N)=O)=O)=O)CO)=O)CCC1)=O)[C@H](CC)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CC%13=CNC=N%13)=O)CC%14=CC=CC=C%14)=O)[C@@H](C)O)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)CO

Molecular Formula

C203H293N55O61S7

Molecular Weight

4704.29

References & Citations

[1]Ruiming Zhao, et al. Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Dec 11;115 (50) :E11847-E11856.