ER-DRI
ER-DRI is a potent peptide inhibitor that tagets EV-A71. ER-DRI directly bounds to 3A and specifically abrogates viral suppressor of RNAi activity, which unlocked the antiviral RNAi response that is suppressed by 3A. ER-DRI also potently inhibits another enterovirus, Coxsackievirus-A16, dependently of RNAi[1].
Product Specifications
UNSPSC
12352209
Target
Enterovirus; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C([C@H](N)CCCNC(N)=N)N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N1[C@@H](C(N2[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(NCC(N[C@@H](C(O)=O)CC3=CC=C(O)C=C3)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC2)=O)CCC1)=O)CCC(O)=O)=O)CCC(O)=O)=O)C(C)C)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC4=CC=C(O)C=C4)=O)CS
Molecular Formula
C118H201N49O30S
Molecular Weight
2818.23
References & Citations
[1]Fang Y, et al. Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity. 2021 Oct 12;54 (10) :2231-2244.e6.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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