MC46 peptide

MC46 (C46) peptide is a membrane-associated fusion peptide inhibitor. mC46 peptide potently inhibits HIV-1 replication and entry. mC46 also inhibits CCR5-tropic, CXCR4-tropic, and dual-tropic HIVs, SIV, and SHIV[1].

Product Specifications

Product Name Alternative

C46 peptide

UNSPSC

12352209

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C([C@@H](N)CC1=CNC2=CC=CC=C12)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CC4=CNC5=CC=CC=C45)=O)CC(N)=O)=O)CC6=CNC7=CC=CC=C67)=O)CC(C)C)=O)CO)=O)C)=O)CC8=CNC9=CC=CC=C89)=O)CCCCN)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CCCCN)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CCC(N)=O)=O)CO)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CO)=O)CC%10=CNC=N%10)=O)[C@H](CC)C)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CC%11=CC=C(O)C=C%11)=O)CC(N)=O)=O)CC(N)=O)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CC%12=CNC%13=CC=CC=C%12%13)=O)CCC(O)=O)=O)CCSC

Molecular Formula

C263H381N67O82S

Molecular Weight

5825.30

References & Citations

[1]Delviks-Frankenberry KA, et al. Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G. Mol Ther Nucleic Acids. 2023 Aug 11;33:794-809.