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LH2 peptide

LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pKa approximately 6) . When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research[1].

Product Specifications

UNSPSC

12352209

Target

Others

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Molecular Formula

C83H128N28O17S2

Molecular Weight

1854.21

References & Citations

[1]Kim J Y, et al. Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics[J]. Peptide Science, 2022, 114 (3) : e24233.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P10794/

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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