P160 peptide

The P160 peptide is a breast cancer-targeting peptide that binds to the keratin 1 (KRT1) receptor on breast cancer cells, with a Kd of approximately 1.1 μM, demonstrating significant potential for targeted drug delivery to breast cancer cells. The P160 peptide enhances the cellular uptake and anticancer activity of the pro-apoptotic antimicrobial peptide MccJ25 (microcin J25) . The P160 peptide can be used in cancer research[1].

Product Specifications

CAS Number

362043-77-4

UNSPSC

12352209

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C([C@H]1N(CCC1)C([C@@H](N)C(C)C)=O)N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56

Molecular Formula

C74H105N17O17S

Molecular Weight

1536.79

References & Citations

[1]Soudy R, et al. Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer. Mol Pharm. 2017 Mar 6;14 (3) :593-604.