Pepinh-MYD (TFA)

Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. Pepinh-MYD TFA interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses. Pepinh-MYD TFA holds potential for studying the role of MyD88 in viral infections[1].

Product Specifications

UNSPSC

12352209

Target

MyD88

Related Pathways

Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Purity

98.86

Smiles

O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CO)=O)CC(N)=O)=O)C(C)C)=O)CS)=O)[C@@H](C)O)=O)=O)CCC1)=O)CC(C)C)=O)C(C)C)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCCCN)=O)CCSC)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCC(N)=O)=O)CC4=CC=CC=C4)=O)CC5=CNC6=CC=CC=C56)=O)[C@H](CC)C)=O)CCCCN)=O)[C@H](CC)C)=O)CCC(N)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C151H248N50O35S2.xC2HF3O2

Molecular Weight

3388.03 (free base)

References & Citations

[1]Takaki H, et al. The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model. J Immunol. 2013 Nov 1;191 (9) :4740-7.