TFE-IDAtp1-LinA

TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA, formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED50 of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP) [1].

Product Specifications

UNSPSC

12352209

Target

Liposome

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCCNCCNCCNCCNC(CN(CC(N[C@H](C(NCCNCCNCCNCCNC(CN(CC(F)(F)F)CC(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC6=CC=C(C=C6)O)C(O)=O)=O)=O)=O)=O)=O)CCCCNC(C(NC(CCCCCCC/C=C/C/C=C/CCCCC)=O)CCCCNC(CCCCCCC/C=C/C/C=C/CCCCC)=O)=O)=O)CC(F)(F)F)=O)=O)=O)=O)[C@H](CCCCN=[N+]=[N-])N

Molecular Formula

C136H204F6N26O22

Molecular Weight

2669.23

References & Citations

[1]Yi Lin, et al. Chemical Evolution of Amphiphilic Xenopeptides for Potentiated Cas9 Ribonucleoprotein Delivery. J Am Chem Soc. 2023 Jul 19;145 (28) :15171-15179.