Pep2m

Pep2m is a peptide receptor inhibitor. Pep2m inhibits the interaction between the C-terminus of the AMPA-type glutamate receptor (GluA2) subunit and N-ethylmaleimide-sensitive fusion protein (NSF) . Pep2m prevents synaptic long-term depression (LTD) . Pep2m can reduce postsynaptic currents in neurons, AMPA-mediated currents in cultured hippocampal neurons, and AMPA receptor surface expression[1][2][3][4][5].

Product Specifications

CAS Number

[243843-42-7]

UNSPSC

12352209

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

NCCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C49H92N18O13S

Molecular Weight

1173.43

References & Citations

[1]Lüthi A, et al.Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct;24 (2) :389-99. |[2]Noel J, et al.Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 1999 Jun;23 (2) :365-76.|[3]Cao F, et al. Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors. Front Synaptic Neurosci. 2018 Nov 13;10:41.|[4]Conboy L, et al. Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action. Neuropsychopharmacology. 2010 Feb;35 (3) :674-85.|[5]Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50 (3) :286-96.