What is the catalog number for Pep4c?

The catalog number for Pep4c is HY-P1057.

What sizes are available for Pep4c?

Pep4c is available in the following size(s): 1 Each.

Pep4c is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Pep4c?

Pep4c is manufactured by QuantiMol.

What is the estimated delivery time for Pep4c?

Estimated delivery time for Pep4c is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Pep4c?

The safety data sheet for Pep4c is available here: http://file.medchemexpress.com/batch_PDF/HY-P1057/.

Pep4c

Pep4c is an inactive control peptide for Pep2m. Pep4c lacks functional activity to disrupt Protein Interacting with C Kinase 1 (PICK1) -AMPA receptor (GluA2) or N-ethylmaleimide-sensitive factor (NSF) -GluA2 interactions. Pep4c is used as a negative control in experiments to validate the specificity of Pep2m's effects on AMPA receptor trafficking and synaptic plasticity[1][2][3][4][5][6].

Product Specifications

CAS Number

243843-43-8

UNSPSC

12352209

Target

IGluR

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C48H91N17O13S

Molecular Weight

1146.41

References & Citations

[1]Noel J, et al. Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism. Neuron. 1999 Jun;23 (2) :365-76.|[2]Lüthi A, et al. Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF-GluR2 interaction. Neuron. 1999 Oct;24 (2) :389-99.|[3]Gallimore AR, et al. Switching On Depression and Potentiation in the Cerebellum. Cell Rep. 2018 Jan 16;22 (3) :722-733. |[4]Cingolani LA, et al. Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins. Neuron. 2008 Jun 12;58 (5) :749-62.|[5]Summa M, et al. Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training. Neuropharmacology. 2011 Dec;61 (8) :1282-90. |[6]Correia SS, et al. Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation. Nat Neurosci. 2008 Apr;11 (4) :457-66.