L57 (acetate)
L57 acetate is a Low-density lipoprotein receptor-related protein 1 (LRP1) -binding peptide. L57 acetate exhibits high affinity to LRP1 with Ki of 45 nM. L57 acetate exhibits blood-brain barrier (BBB) permeability and plasma stability. L57 acetate can be utilized as the carrier for CNS drug delivery[1].
Product Specifications
UNSPSC
12352209
Target
LDLR
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Purity
99.01
Smiles
O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC9=CNC=N9)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N.CC(O)=O.[x]
Molecular Formula
C120H175N31O27.xC2H4O2
Molecular Weight
2483.87 (free base)
References & Citations
[1]Sakamoto K, et al., A novel LRP1-binding peptide L57 that crosses the blood brain barrier. Biochem Biophys Rep. 2017 Aug 12;12:135-139.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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