RTDLDSLRTYTL (TFA)

RTDLDSLRTYTL TFA is an Alpha (v) beta (6) integrin (avb6) inhibitor with high affinity and specificity. RTDLDSLRTYTL TFA binds to avb6 integrin, a peptide sequence that activates cytotoxicity and cytokine production in T cells, such as interferon-gamma. RTDLDSLRTYTL TFA is designed through a chimeric T cell antigen receptor (CAR) so that T cells can be redirected to specifically recognize and attack tumor cells. RTDLDSLRTYTL TFA can be used in the research of cancer immunotherapy and targeted drug development[1].

Product Specifications

UNSPSC

12352209

Target

IFNAR; Integrin

Related Pathways

Cytoskeleton; Immunology/Inflammation

Field of Research

Cancer

Smiles

OC(C(F)(F)F)=O.OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)[C@@H](C)O)=O)CC(O)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@@H](C)O)=O)C=C1

Molecular Formula

C64H105F3N18O24

Molecular Weight

1567.62

References & Citations

[1]Pameijer C R J, et al. Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor[J]. Cancer gene therapy, 2007, 14 (1) : 91-97.