Tat-CBD3 (TFA)

Tat-CBD3 TFA, a 15-amino acid peptide from CRMP2, fused to the TAT cell-penetrating motif of the HIV-1 protein, disrupts CRMP2-NMDAR interaction without change in NMDAR localization[1].

Product Specifications

UNSPSC

12352209

Target

HIV; iGluR

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C([C@@H](N)CC1=CC=C(O)C=C1)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N2[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CCC2)=O)C(C)C)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CO)=O)CCCNC(N)=N)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O.O=C(O)C(F)(F)F.[x]

Molecular Formula

C134H243N59O32.xHC2O2F3

Molecular Weight

3192.74 (free base)

References & Citations

[1]Tatiana Brustovetsky, et al. Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity. J Biol Chem. 2014 Mar 14;289 (11) :7470-82.