Ac-DEVD-CHO (TFA)
Ac-DEVD-CHO TFA is a peptide inhibitor of caspase-3 (Ki=230 pM) and caspase-7. Ac-DEVD-CHO TFA reduces caspase-3 activity and apoptosis induced by Prostaglandin E2 in rat cortical neurons. Ac-DEVD-CHO TFA is promising for research of neurodegenerative diseases and cancers[1][2].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Smiles
FC(C(O)=O)(F)F.O=C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O
Molecular Formula
C22H31F3N4O13
Molecular Weight
616.50
References & Citations
[1]Takadera T, et al. Prostaglandin E (2) induces caspase-dependent apoptosis in rat cortical cells. Neurosci Lett. 2002 Jan 11;317 (2) :61-4.|[2]Garcia-Calvo M, et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 1998 Dec 4;273 (49) :32608-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 7
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