DB21, Galectin-1 Antagonist
DB21, Galectin-1 Antagonist is a dibenzofuran conjugated peptidomimetic that acts as an allosteric inhibitor of galectin-1 (GAL1) binding to cell surface glycans. DB21, Galectin-1 Antagonis increases inhibition of angiogenesis and tumour growth in melanoma, lung adenocarcinoma and ovarian cancer models[1].
Product Specifications
CAS Number
1623027-80-4
UNSPSC
12352209
Target
Galectin
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC(CCC1=CC=CC2=C1OC3=C2C=CC=C3CCNC([C@H](CC(C)C)NC([C@@H](NC([C@@H](CCC)NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@H](CO)N)=O)=O)=O)=O)CCCCN)=O)=O)=O
Molecular Formula
C83H136N18O19
Molecular Weight
1690.08
References & Citations
[1]Karina V Mariño, et al. Targeting galectin-driven regulatory circuits in cancer and fibrosis. Nat Rev Drug Discov. 2023 Apr;22 (4) :295-316.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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