Bradykinin (triacetate)

Bradykinin triacetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin triacetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain[1][2][3][4][5].

Product Specifications

CAS Number

[5979-11-3]

UNSPSC

12352209

Target

Bradykinin Receptor; Endogenous Metabolite; Ser/Thr Protease

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Endocrinology; Cardiovascular Disease

Smiles

O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@@H](CO)C(N2[C@@H](CCC2)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CC=CC=C4)=O)=O)[C@H]5N(CCC5)C([C@@H](N)CCCNC(N)=N)=O.CC(O)=O.CC(O)=O.CC(O)=O

Molecular Formula

C56H85N15O17

Molecular Weight

1240.36

References & Citations

[1]Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95 (5) :1115-8. |[2]Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32 (4) :1709-14. |[3]Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37 (4) :1592-606.|[4]Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62.|[5]Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19 (14) :2646-50.