[Phe1Ψ (CH2-NH) Gly2]Nociceptin (1-13) NH2

[Phe1Ψ (CH2-NH) Gly2]Nociceptin (1-13) NH2 is a nociceptin receptor (ORL1) agonist. [Phe1Ψ (CH2-NH) Gly2]Nociceptin (1-13) NH2 strongly depresses the nociceptive flexor reflex in rats. [Phe1Ψ (CH2-NH) Gly2]Nociceptin (1-13) NH2 can be used for analgesia research[1].

Product Specifications

CAS Number

[213130-17-7]

UNSPSC

12352209

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

NCCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC(CNC([C@H]([C@H](O)C)NC([C@H](CC1=CC=CC=C1)NC(CNC(CNC[C@@H](N)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C61H102N22O14

Molecular Weight

1367.60

References & Citations

[1]Xu IS, et al. [Phe1psi (CH2-NH) Gly2]-nociceptin- (1-13) NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci Lett. 1998 Jun 19;249 (2-3) :127-30.