Taspoglutide (acetate)
Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM) . Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model[1][2].
Product Specifications
CAS Number
[1022150-16-8]
Product Name Alternative
ITM077 (acetate) ; R1583 (acetate) ; BIM51077 (acetate)
UNSPSC
12352209
Target
GLP Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
Molecular Formula
C152H232N40O45.xC2H4O2
Molecular Weight
3339.71 (free base)
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P0165B/
Scientific Category
Peptides
Clinical Information
Phase 3
Available Sizes
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