Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Taspoglutide (acetate)

Taspoglutide (R1583) acetate is an agonist of the glucagon-like peptide 1 receptor (GLP-1R) with an Ki value of 1.1 nM. Taspoglutide acetate induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM) . Taspoglutide acetate decreases blood levels of glucose and increases blood levels of insulin in a glucose tolerance test in Zucker diabetic obese rats. Taspoglutide acetate reduces blood levels of gastric inhibitory polypeptide (GIP), plasma levels of triglycerides, and body weight in the same model[1][2].

Product Specifications

CAS Number

[1022150-16-8]

Product Name Alternative

ITM077 (acetate) ; R1583 (acetate) ; BIM51077 (acetate)

UNSPSC

12352209

Target

GLP Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

N=C(NCCC[C@H](NC(C(C)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=CC=CC=C12)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC(CNC([C@@H](NC(C(C)(NC([C@H](CC6=CN=CN6)N)=O)C)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)C(C)C)=O)CO)=O)CO)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCN)=O)CCC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)=O)CC(C)C)=O)C(C)C)=O)CCCCN)=O)C)=O)C(N)=O)N.CC(O)=O.[x]

Molecular Formula

C152H232N40O45.xC2H4O2

Molecular Weight

3339.71 (free base)

References & Citations

[1]Dong JZ, et al. Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes. Diabetes Obes Metab. 2011 Jan;13 (1) :19-25.|[2]Sebokova E, et al. Taspoglutide, a novel human once-weekly analogue of glucagon-like peptide-1, improves glucose homeostasis and body weight in the Zucker diabetic fatty rat. Diabetes Obes Metab. 2010 Aug;12 (8) :674-82.

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P0165B/

Scientific Category

Peptides

Clinical Information

Phase 3

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant Brucella abortus Probable intracellular septation protein A (BAbS19_I18150)
MBS1034922 Inquire

Recombinant Brucella abortus Probable intracellular septation protein A (BAbS19_I18150)

Ask
View Details
Angiopoietin 1 (ANGPT1) Human qPCR Primer Pair (NM_001146)
HP205085 200 Reactions

Angiopoietin 1 (ANGPT1) Human qPCR Primer Pair (NM_001146)

Ask
View Details
Recombinant Human TRIM29 Protein, N-His-SUMO
HC430012-01 50 µg

Recombinant Human TRIM29 Protein, N-His-SUMO

Ask
View Details
Recombinant Human TRIM29 Protein, N-His-SUMO
HC430012-02 100 µg

Recombinant Human TRIM29 Protein, N-His-SUMO

Ask
View Details
Recombinant Human TRIM29 Protein, N-His-SUMO
HC430012-03 1 mg

Recombinant Human TRIM29 Protein, N-His-SUMO

Ask
View Details