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Octreotide (dihydrochloride)

Octreotide (SMS 201-995) hydrochloride is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide hydrochloride can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide hydrochloride increases Gi activity and reduces intracellular cAMP production. Octreotide hydrochloride has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].

Product Specifications

CAS Number

1607842-55-6

Product Name Alternative

SMS 201-995 (dihydrochloride)

UNSPSC

12352209

Target

Apoptosis; Somatostatin Receptor

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer; Endocrinology; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@H](CO)[C@H](O)C)=O)NC([C@H](N)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N[C@@H]1CC4=CNC5=CC=CC=C45.Cl.Cl

Molecular Formula

C49H68Cl2N10O10S2

Molecular Weight

1092.16

References & Citations

[1]Octreotide pamoate, OncoLAR, OP-LAR|[2]Chand Khanna, et al. A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy. Clin Cancer Res. 2002 Jul;8 (7) :2406-12.|[3]Xiao-Xia Wang, et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16 (1) :109-118.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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