Lacto-N-tetraose

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula[1].

Product Specifications

CAS Number

[14116-68-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Purity

95.0

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

CC(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)[C@@H]1O[C@@H]3[C@H]([C@@H](O[C@@H]([C@@H]3O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)=O

Molecular Formula

C26H45NO21

Molecular Weight

707.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu Y, et al. Physiological effects, biosynthesis, and derivatization of key human milk tetrasaccharides, lacto-N-tetraose, and lacto-N-neotetraose. Crit Rev Biotechnol. 2022 Jun;42 (4) :578-596.|[2]Craft KM, Thomas HC, Townsend SD. Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus. Org Biomol Chem. 2019 Feb 13;17 (7) :1893-1900.|[3]Phipps KR, et al. Preclinical safety evaluation of the human-identical milk oligosaccharide lacto-N-tetraose. Regul Toxicol Pharmacol. 2018 Nov;99:260-273.