Lacto-N-neotetraose

Lacto-N-neotetraose (LNnT) is an endogenous metabolite. Lacto-N-neotetraose can inhibit TNF-α induced IL-8 secretion in immature epithelial cells. Lacto-N-neotetraose has anti-inflammatory avtivity, and can improve the wound closure[1][2][4].

Product Specifications

CAS Number

[13007-32-4]

Product Name Alternative

LNnT

UNSPSC

12352005

Target

Endogenous Metabolite; TNF Receptor

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

99.71

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

CC(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)CO)O)[C@@H]1O[C@@H]3[C@H]([C@@H](O[C@@H]([C@@H]3O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)=O

Molecular Formula

C26H45NO21

Molecular Weight

707.63

References & Citations

[1]Xiaomin Dong, et al. CRISPRi-Guided Multiplexed Fine-Tuning of Metabolic Flux for Enhanced Lacto- N-neotetraose Production in Bacillus subtilis. J Agric Food Chem. 2020 Feb 26;68 (8) :2477-2484. |[2]Lianghui Cheng, et al. The Human Milk Oligosaccharides 3-FL, Lacto-N-Neotetraose, and LDFT Attenuate Tumor Necrosis Factor-α Induced Inflammation in Fetal Intestinal Epithelial Cells In Vitro through Shedding or Interacting with Tumor Necrosis Factor Receptor 1. Mol Nutr Food Res. 2021 Apr;65 (7) :e2000425. |[3]I Idänpään-Heikkilä, et al. Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia. J Infect Dis. 1997 Sep;176 (3) :704-12. |[4]Behrouz Farhadihosseinabadi, et al. The in vivo effect of Lacto-N-neotetraose (LNnT) on the expression of type 2 immune response involved genes in the wound healing process. Sci Rep. 2020 Jan 22;10 (1) :997.