(rac) -Poriol
(rac) -Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC50 of 0.18 µg/mL. (rac) -Poriol inhibits the LPS (HY-D1056) -induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac) -Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β[1].
Product Specifications
CAS Number
[70460-58-1]
Product Name Alternative
5,7,4'-Trihydroxy-6-methylflavanone
UNSPSC
12352005
Target
COX; Interleukin Related; NO Synthase
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(C(C)=C(C=C2OC(C1)C3=CC=C(C=C3)O)O)O
Molecular Formula
C16H14O5
Molecular Weight
286.28
References & Citations
[1]Sucahyo A, et al. Flavanones from ethyl acetate fraction of Caesalpinia sappan heartwood as anti-inflammatory and antioxidant: Isolation, in-vitro, and in-silico approach[C]//AIP Conference Proceedings. AIP Publishing, 2024, 3055 (1) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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