Masticadienonic acid
Masticadienonic acid is an orally active and selective inhibitor of MAPK (p38, ERK, JNK) and NF-κB pathways and an agonist of the Nrf2 pathway. Masticadienonic acid reduces the release of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, restores the expression of intestinal tight junction proteins (ZO-1, occludin), and modulates gut microbiota. Masticadienonic acid is promising for research of inflammatory bowel disease[1].
Product Specifications
CAS Number
514-49-8
UNSPSC
12352211
Target
Keap1-Nrf2; NF-κB; p38 MAPK
Related Pathways
MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
C[C@@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)[C@@]3([H])CC[C@]1([C@](CC2)([H])[C@@H](C)CC/C=C(C)\C(O)=O)C
Molecular Formula
C30H46O3
Molecular Weight
454.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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