Masticadienonic acid

Masticadienonic acid is an orally active and selective inhibitor of MAPK (p38, ERK, JNK) and NF-κB pathways and an agonist of the Nrf2 pathway. Masticadienonic acid reduces the release of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, restores the expression of intestinal tight junction proteins (ZO-1, occludin), and modulates gut microbiota. Masticadienonic acid is promising for research of inflammatory bowel disease[1].

Product Specifications

CAS Number

[514-49-8]

UNSPSC

12352211

Target

Keap1-Nrf2; NF-κB; p38 MAPK

Related Pathways

MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

C[C@@]12C3=CC[C@](C(C)(C(CC4)=O)C)([H])[C@@]4(C)[C@@]3([H])CC[C@]1([C@](CC2)([H])[C@@H](C)CC/C=C(C)\C(O)=O)C

Molecular Formula

C30H46O3

Molecular Weight

454.68

References & Citations

[1]Cui H, et al. Masticadienonic acid from Chios mastic gum mitigates colitis in mice via modulating inflammatory response, gut barrier integrity and microbiota. Phytomedicine. 2023 Jan;108:154518.