Ilicicolin H
Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection[1][2].
Product Specifications
CAS Number
[12689-26-8]
UNSPSC
12352005
Hazard Statement
H335
Target
Apoptosis; Fungal; Phosphoglycerate Kinase (PGK)
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer; Infection
Smiles
O=C1C(C([C@H]2[C@H](/C=C/C)[C@@]3([H])C[C@@H](C)CC[C@]3([H])C(C)=C2)=O)=C(O)C(C4=CC=C(O)C=C4)=CN1
Molecular Formula
C27H31NO4
Molecular Weight
433.54
Precautions
P261-P271-P304+P340-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N8540/
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PGK1
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