Myrothecine A
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively[1][2][3].
Product Specifications
CAS Number
910292-40-9
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Cytochrome P450; JNK; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC1([C@@](OC(/C=C\CC[C@@]23C(C)=O)=O)([H])C[C@@]4([H])O5)[C@](CC[C@](O)6C)(COC(/C=C(CCO3)\[C@H]2O)=O)[C@H]5[C@]6([H])CC14O
Molecular Formula
C29H38O10
Molecular Weight
546.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bax; Caspase 3; Caspase 5; Caspase 8
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