Aphidicolin 17-acetate
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses[1].
Product Specifications
CAS Number
[51103-57-2]
Product Name Alternative
Aphidicolin 17-monoacetate
UNSPSC
12352211
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O[C@]1(COC(C)=O)CC[C@@]23[C@@]([C@@]4([H])CC[C@@]2([H])C[C@@H]1C3)(C)CC[C@@H](O)[C@@]4(C)CO
Molecular Formula
C22H36O5
Molecular Weight
380.52
References & Citations
[1]Haraguchi T, et al. Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate. Nucleic Acids Res. 1983 Feb 25;11 (4) :1197-209.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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