4,6-O-Ethylidene-α-D-glucose (Standard)
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport[1][2][3].
Product Specifications
CAS Number
13224-99-2
UNSPSC
12352005
Target
Endogenous Metabolite; GLUT
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
[H][C@]12[C@@](O[C@H](O)[C@H](O)[C@H]2O)([H])COC(C)O1
Molecular Formula
C8H14O6
Molecular Weight
206.19
References & Citations
[1]M Hashiramoto, et al. Site-directed Mutagenesis of GLUT1 in Helix 7 Residue 282 Results in Perturbation of Exofacial Ligand Binding. J Biol Chem. 1992 Sep 5;267 (25) :17502-7.|[2]Malay Patra, et al. A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells. Angew Chem Int Ed Engl. 2016 Feb 12;55 (7) :2550-4.|[3]G F Baker, et al. The Permeation of Human Red Cells by 4,6-O-ethylidene- -D-glucopyranose (Ethylidene Glucose) . J Physiol. 1973 May;231 (1) :129-42.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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