Galbacin

Galbacin ((3S) -Zuonin A), the epimer of (-) -Zuonin A (HY-N7394A), is a AMPK activator. Galbacin can be isolated from Myristica fragrans (nutmeg) . Galbacin stimulates AMPK enzyme in differentiated C2C12 cells. Galbacin also has anticancer activity, and inhibits the proliferation of lymphocyte and tumor cells. Galbacin prevents weight gain in diet-induced mice model. Galbacin can be used for metabolic syndrome (including obesity and type-2 diabetes) and caners research[1][2].

Product Specifications

CAS Number

[528-64-3]

Product Name Alternative

(3S) -Zuonin A

UNSPSC

12352005

Target

AMPK

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Field of Research

Cancer; Metabolic Disease

Smiles

C[C@H]1[C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)O[C@@H]1C4=CC=C(OCO5)C5=C4

Molecular Formula

C20H20O5

Molecular Weight

340.37

References & Citations

[1]Nascimento M S J, et al. Effect of natural 2, 5-diaryl-3, 4-dimethyltetrahydrofuran lignans on complement activation, lymphocyte proliferation, and growth of tumor cell lines[J]. Pharmaceutical biology, 2004, 42 (6) : 449-453.|[2]Nguyen PH, et al. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett. 2010 Jul 15;20 (14) :4128-31.