Galbacin
Galbacin ((3S) -Zuonin A), the epimer of (-) -Zuonin A , is a AMPK activator. Galbacin can be isolated from Myristica fragrans (nutmeg). Galbacin stimulates AMPK enzyme in differentiated C2C12 cells. Galbacin also has anticancer activity, and inhibits the proliferation of lymphocyte and tumor cells. Galbacin prevents weight gain in diet-induced mice model. Galbacin can be used for metabolic syndrome (including obesity and type-2 diabetes) and caners research[1][2].
Product Specifications
CAS Number
528-64-3
Product Name Alternative
(3S) -Zuonin A
UNSPSC
12352005
Target
AMPK
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Field of Research
Cancer; Metabolic Disease
Smiles
C[C@H]1[C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)O[C@@H]1C4=CC=C(OCO5)C5=C4
Molecular Formula
C20H20O5
Molecular Weight
340.37
References & Citations
[1]Nascimento M S J, et al. Effect of natural 2, 5-diaryl-3, 4-dimethyltetrahydrofuran lignans on complement activation, lymphocyte proliferation, and growth of tumor cell lines[J]. Pharmaceutical biology, 2004, 42 (6) : 449-453.|[2]Nguyen PH, et al. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett. 2010 Jul 15;20 (14) :4128-31.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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